Standardization of the national reference anti-HBs immunoglobulin by radioimmunoassay

The method for assaying potency of anti-HBs immunoglobulin (HBIG) developed in our Department was applied to the standardization of the Japanese national reference HBIG preparation which is specified in the Minimum Requirements for Biological Products. The method was studied for utility in routine anti-HBs determination. The reference HBIG preparation proved to be satisfactorily stable.