[Erythrocyte enzymes and 2,3-diphosphoglycerate in juvenile diabetics]

The activity levels of phosphoglyceromutase, Glucose-6-P-dehydrogenase. 3-P-Glyceratkinase and Glutathionreductase of the erythrocytes as well as 2,3-Diphosphoglycerate were determined in a total of 263 children suffering from juvenile diabetes mellitus. They were divided into two groups: 103 diabetics with a good state of metabolic control and 103 diabetics with a bad control. The results of 57 diabetic children were rejected. The enzyme activities have been shown to vary. PGM activity was increased in all diabetics, G-6-PDH only in such with bad condition of metabolic control. The activity of 3-PGK was significantly diminished, Glutathionreductase activity was indifferent in both groups. Until today we don't found results of other authors determining these enzymes. The changes of some enzyme activities in diabetics may be due to hormonal mechanisms by insulin.