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Maximum oxygen consumption and catecholamines in thyroidectomized dogs

A Therminarias, A Lucas

    Pflugers Archiv : European Journal of Physiology
    |November 11, 1982
    PubMed
    Summary
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    Thyroidectomy in dogs significantly impacts cold-induced heat production more than exercise capacity. Increased catecholamines after thyroidectomy help limit heat loss but do not fully compensate for reduced thyroid hormone function.

    Area of Science:

    • Veterinary Physiology
    • Endocrinology

    Background:

    • Thyroid hormones play a crucial role in regulating metabolism and thermogenesis.
    • Thyroidectomy, the surgical removal of the thyroid gland, leads to a deficiency in thyroid hormones.

    Purpose of the Study:

    • To investigate the effects of thyroidectomy on maximum oxygen consumption (Vo2 max) under cold stress and exhaustive exercise conditions in dogs.
    • To assess the impact of thyroidectomy on plasma catecholamine and substrate concentrations during these physiological challenges.

    Main Methods:

    • Comparisons of maximum oxygen consumption (CVo2 max and Ex Vo2 max) were made in 7 dogs before and after thyroidectomy.
    • Measurements included heart rate, plasma catecholamine (epinephrine, norepinephrine), and substrate (glucose, lactic acid, FFA) concentrations.

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    Main Results:

    • Thyroidectomy caused a greater reduction in cold-induced Vo2 max (CVo2 max) than in exercise-induced Vo2 max (Ex Vo2 max).
    • In T dogs, plasma epinephrine and norepinephrine levels increased more significantly under cold stress, correlating with CVo2 max.
    • Plasma FFA levels were elevated in T dogs during cold stress, while other substrates remained similar.

    Conclusions:

    • Thyroidectomy primarily affects heat production mechanisms rather than muscular exercise capacity in dogs.
    • Increased catecholamine secretion post-thyroidectomy partially mitigates the decrease in heat production during cold exposure.
    • The observed effects suggest thyroidectomy may lead to decreased beta-receptor sensitivity, with catecholamines only partially compensating.