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Related Experiment Videos

Serum bromine levels in psoriasis

J Shani, S Barak, M Ram

    Pharmacology
    |January 1, 1982
    PubMed
    Summary

    Bathing in the Dead Sea significantly increased serum bromine levels in patients with psoriasis, correlating with clinical improvements. Exposure to bromine-rich air and water appears to be the primary cause.

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    Area of Science:

    • Environmental Medicine
    • Dermatology
    • Clinical Chemistry

    Background:

    • Psoriasis is a chronic inflammatory skin condition.
    • The Dead Sea is known for its unique mineral composition, including high bromine concentrations.
    • Previous studies suggest potential therapeutic benefits of Dead Sea treatments for psoriasis.

    Purpose of the Study:

    • To investigate the impact of Dead Sea bathing on serum bromine levels in patients with psoriasis.
    • To correlate changes in serum bromine with clinical and psychological improvements.
    • To explore the role of bromine exposure from both water and aerosol in the Dead Sea environment.

    Main Methods:

    • Serum bromine levels were measured in Danish patients with psoriasis before and after a 4-week Dead Sea bathing course.

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  • Serum bromine levels were also assessed in healthy and occupationally exposed Israeli populations.
  • Animal studies were conducted to determine the skin's absorption of bromine (82Br).

    • Main Results:

    • Serum bromine levels in psoriatic Danes increased 2- to 3-fold after Dead Sea bathing, correlating with symptom improvement.
    • Serum bromine levels in Israelis working outdoors in the Dead Sea area were significantly higher than those in indoor workers or Jerusalem residents.
    • Animal experiments confirmed the skin as a primary absorption site for bromine via bathing and aerosol exposure.

    Conclusions:

    • Dead Sea bathing leads to a significant increase in serum bromine levels in psoriatic patients.
    • The observed increase in bromine is linked to both therapeutic benefits and environmental exposure (water and aerosol).
    • The skin plays a crucial role in the absorption of environmental bromine.