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The Bucharest multifactorial prevention trial. The changes of morbidity and of general and specific mortality
Insights
The Bucharest trial demonstrated significant reductions in cardiovascular events and mortality through multifactorial prevention strategies. This intervention effectively lowered heart disease incidence and outcomes over five years compared to the control group.
Area of Science:
- Cardiovascular Medicine
- Preventive Cardiology
- Public Health Interventions
Background:
- Coronary heart disease (CHD) poses a significant global health burden.
- Multifactorial prevention strategies are crucial for mitigating cardiovascular risk.
- Long-term data on the efficacy of comprehensive prevention trials are essential.
Purpose of the Study:
- To evaluate the impact of a multifactorial prevention program on cardiovascular morbidity and mortality.
- To assess the 5-year outcomes of the Bucharest Multifactorial Prevention Trial.
- To compare the incidence of major cardiovascular events between intervention and control groups.
Main Methods:
- A prospective, controlled trial design was employed.
- Participants were allocated to either an intervention or a control group.
- Age-adjusted rates of cardiovascular events and mortality were analyzed over a 5-year follow-up period.
Main Results:
- The intervention group showed a statistically significant 41% reduction in hard cardiovascular events (myocardial infarction, stroke, acute coronary insufficiency).
- Significant decreases were observed for myocardial infarction (35%), coronary mortality (38%), stroke (39%), and overall cardiovascular mortality (30%).
- Evolution curves demonstrated a clear divergence between groups, with the control group experiencing higher morbidity and mortality rates after 5 years.
Conclusions:
- Multifactorial prevention strategies are highly effective in reducing cardiovascular morbidity and mortality.
- The Bucharest trial provides robust evidence supporting the long-term benefits of comprehensive CHD prevention.
- The findings underscore the importance of sustained intervention for improving cardiovascular health outcomes.
Abstract:
The paper presents the results of the Bucharest multifactorial prevention trial of coronary heart disease, concerning changes in cardiovascular morbidity and mortality during the first 5-year-period of follow-up. The age adjusted 5-year-rates disclose important reductions in the intervention group in comparison with the control one: for hard events (myocardial infarction, stroke, acute coronary insufficiency)--by 41%; for myocardial infarction--by 35%; for coronary mortality--by 38%; for stroke--by 39%; for cardiovascular mortality--by 30%. The decrease of hard events, myocardial infarction and stroke incidences are statistical significant. The evolution curves of cardiovascular morbidity and mortality show that both groups (the intervention as well as the control one) began with near the same values, but on the way and especially after 5 years they are differently located, those of the control group being higher than those of the intervention group.