Related Experiment Video
Updated: Aug 15, 2026
07:51
Synovial Fluid Analysis to Identify Osteoarthritis
Published on: October 20, 2022
[Changes in the synovial membrane in psoriatic arthritis]
Revue Du Rhumatisme Et Des Maladies Osteo-Articulaires
|October 1, 1982
Summary
Psoriatic arthritis synovial membrane shows cell infiltrates, fibroblast response, blood vessel changes, and fibrosis. However, these microscopic features alone cannot definitively diagnose psoriatic arthritis.
Area of Science:
- Rheumatology
- Histopathology
- Immunology
Context:
- Psoriatic arthritis (PsA) is a chronic inflammatory disease.
- Synovial membrane changes are key in PsA pathogenesis.
- Accurate histopathological diagnosis is crucial for patient management.
Purpose:
- To detail the characteristic structural alterations of the synovial membrane in psoriatic arthritis.
- To evaluate the diagnostic specificity of these histopathological findings.
Summary:
- Synovial changes in psoriatic arthritis include focal/diffuse cell infiltrates (predominantly plasmocytes), activated synoviocytes/fibroblasts, vascular alterations, and fibrosis.
- While these features are typical, no single histopathological finding is pathognomonic for psoriatic arthritis.
- Microscopic examination alone is insufficient for a definitive PsA diagnosis.
Impact:
- Provides a detailed histopathological profile of the psoriatic arthritis synovium.
- Highlights the limitations of relying solely on microscopic analysis for PsA diagnosis.
- Informs differential diagnosis and underscores the need for integrated diagnostic approaches.
Related Concept Videos
01:23Glycosaminoglycans
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
01:16Structural Joints: Synovial Joints
Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
01:23Knee Joint
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...
01:10Ankle Joint
The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
01:07Development of the Limb Synovial Joints
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
01:24T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...