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Renal contribution to plasma catecholamines--effect of age
Scandinavian Journal of Clinical and Laboratory Investigation
|September 1, 1982
Summary
This study shows the kidneys release more noradrenaline and absorb less adrenaline as people age. Age significantly impacts kidney catecholamine handling and plasma concentrations.
Area of Science:
- Cardiovascular Physiology
- Renal Physiology
- Endocrinology
Background:
- Plasma catecholamine levels are crucial for cardiovascular regulation.
- The kidney's role in catecholamine metabolism is not fully understood.
- Age-related changes in endocrine function may affect renal catecholamine handling.
Purpose of the Study:
- To investigate renal venous-arterial differences in noradrenaline and adrenaline.
- To determine the influence of age on renal catecholamine secretion and uptake.
- To assess the impact of age on plasma catecholamine concentrations.
Main Methods:
- Cardiac catheterization in 18 subjects.
- Measurement of arterial and renal venous noradrenaline and adrenaline.
- Correlation analysis between age and catecholamine levels/differences.
Main Results:
- Renal venous noradrenaline was significantly higher than arterial noradrenaline.
- Arterial adrenaline was significantly higher than renal venous adrenaline, indicating renal uptake.
- Age positively correlated with renal noradrenaline release and negatively with renal adrenaline uptake.
Conclusions:
- The kidneys actively secrete noradrenaline and take up adrenaline.
- Age-related changes in renal catecholamine handling occur, with decreased adrenaline uptake and increased noradrenaline release.
- Age influences plasma catecholamine levels, potentially due to adrenal medulla involution and altered renal function.