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Epicardial Outgrowth Culture Assay and Ex Vivo Assessment of Epicardial-derived Cell Migration
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Epicardial Outgrowth Culture Assay and Ex Vivo Assessment of Epicardial-derived Cell Migration

Published on: March 18, 2016

Myocardial covering on epicardial coronary arteries. Prevalence, localization and significance

B F Hansen

    Scandinavian Journal of Thoracic and Cardiovascular Surgery
    |January 1, 1982
    PubMed

    Insights

    Myocardial bridges, where coronary arteries are covered by heart muscle, commonly affect the left anterior descending artery. This can lead to artery narrowing and blood clots, but surgical treatment shows promise.

    Area of Science:

    • Cardiovascular anatomy and pathology
    • Interventional cardiology

    Background:

    • Epicardial coronary arteries can be covered by myocardial musculature, forming myocardial bridges.
    • These bridges predominantly involve the left anterior descending artery (LAD).

    Purpose of the Study:

    • To investigate the specific predilection of mural-covered LAD segments for arteriosclerotic stenosis and thrombosis.
    • To highlight the angiographic "milking effect" indicative of myocardial bridging.
    • To report on the efficacy of surgical myotomy for treating associated pathologies.

    Main Methods:

    • Angiographic analysis to identify and characterize myocardial bridging.
    • Correlation of bridging with prevalence of arteriosclerotic stenosis and coronary thrombosis.
    • Evaluation of surgical outcomes following myotomy.

    Main Results:

    • Premural segments of the LAD artery are identified as sites of predilection for arteriosclerotic stenosis and coronary thrombosis.
    • The "milking effect" on angiography is a key indicator of myocardial covering.
    • Surgical myotomy has demonstrated successful outcomes in correcting these conditions.

    Conclusions:

    • Myocardial bridging of the LAD artery is a significant factor in the development of coronary artery disease.
    • "Milking effect" is a crucial diagnostic sign.
    • Surgical intervention, specifically myotomy, offers a viable treatment option for symptomatic myocardial bridging.

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