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[Digitalization without saturation dose using methyldigoxin. Experiences with 29 patients]

G Salvadè, R Tartini, T Moccetti

    Schweizerische Medizinische Wochenschrift
    |December 11, 1982
    PubMed
    Summary
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    Starting oral digitalization with a daily maintenance dose of methyldigoxin effectively achieved therapeutic plasma levels in most cardiac insufficiency patients. This approach demonstrated clinical improvement without significant dose adjustments, highlighting its practical utility.

    Area of Science:

    • Cardiology
    • Pharmacology

    Context:

    • Assessing the efficacy of oral digitalization without a saturation dose.
    • Evaluating clinical parameters and plasma digitalis levels in patients with cardiac insufficiency.

    Purpose:

    • To determine the indications and performance of initiating oral digitalization with a daily maintenance dose of methyldigoxin.
    • To establish therapeutic plasma levels and clinical response in cardiac insufficiency patients.

    Summary:

    • A daily maintenance dose of methyldigoxin (0.2 mg) was administered to 29 patients with cardiac insufficiency.
    • Therapeutic plasma levels (0.8-2.0 ng/ml) were achieved in 28 patients, with a mean concentration of 1.47 +/- 0.4 ng/ml.
    • Clinical improvement was observed in 18 patients, with stable plasma levels and minimal ECG alterations over 30 days. Renal insufficiency correlated with creatinine levels.

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    Impact:

    • Provides evidence for the effectiveness of a simplified oral digitalization regimen.
    • Suggests a practical approach for managing cardiac insufficiency with methyldigoxin.
    • Highlights the importance of monitoring plasma levels, especially in patients with renal impairment.