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Updated: Oct 23, 2026

Multicellular Human Alveolar Model Composed of Epithelial Cells and Primary Immune Cells for Hazard Assessment
Published on: May 6, 2020
[Effect of contactin from the lung on the cellular proliferative activity of the alveolar wall]
Abstract:
The influence of contactine from rat lung on DNA synthesis in pulmonary alveolar tissue of A mice was studied in vivo. Two-fold decrease in the total index of pulmonary tissue cells labeled with 3H-thymidine was observed 7-24 hours following the contactine injection. The inhibition of DNA syntheses was observed at the same concentrations at which a cell cohesion increases. The results presented indicate that the effect of contactine on proliferative activity in vivo may be realized through its influence on cell cohesion.
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