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Electron microscopic studies on pulmonary alveolar microlithiasis

M Kawakami, S Sato, T Takishima

    The Tohoku Journal of Experimental Medicine
    |December 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

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    Pulmonary alveolar microlithiasis involves tiny calcium phosphate deposits in the lungs. Microscopic analysis reveals these microliths grow by surface deposition and exhibit unique internal structures.

    Area of Science:

    • Pulmonary Medicine
    • Pathology
    • Electron Microscopy

    Background:

    • Pulmonary alveolar microlithiasis (PAM) is a rare lung disease characterized by diffuse microlith formation within alveoli.
    • Understanding the morphology of these microliths is crucial for diagnosing and managing PAM.

    Observation:

    • Scanning electron microscopy (SEM) visualized microliths with globular, irregular, or lobulated shapes, often coalesced.
    • The outer surface of microliths appeared granular or rough, with surface deposits.
    • Transmission electron microscopy (TEM) revealed concentric laminar internal structures within the microliths.

    Findings:

    • Microliths exhibit layered growth patterns, suggesting formation by surface deposition and early-stage coalescence.
    • SEM identified surface granules, while TEM revealed scale-like structures and electron-dense bodies within microliths.

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  • TEM also noted elastosis in the alveolar interstitium and abundant glycogen in bronchiolar epithelial cells.

    • Implications:

    • The observed morphology supports a model of microlith formation via accretion and aggregation.
    • These detailed ultrastructural findings enhance our understanding of PAM pathogenesis.
    • Further research into microlith composition and formation mechanisms may reveal therapeutic targets.