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[Drug induced esophageal ulcers]

H E Hügel, H Schinko, H P Bischof

    Zeitschrift Fur Gastroenterologie
    |October 1, 1982
    PubMed
    Summary

    Drug-induced esophageal ulcers from medications like doxycycline can occur suddenly, especially when taken with minimal fluid before bed. Retrosternal burning, odynophagia, and dysphagia are key symptoms requiring endoscopic diagnosis.

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    Coffee, tea, and lifestyle.

    Preventive medicine·1994

    Area of Science:

    • Gastroenterology
    • Internal Medicine
    • Pharmacology

    Background:

    • Drug-induced esophageal ulcers are an underrecognized clinical issue.
    • Certain medications, including doxycycline-hydrochloride, metacycline-hydrochloride, and emeproniumbromide, have been implicated.

    Observation:

    • Four cases of esophageal ulcers were identified over six years.
    • Symptoms like retrosternal burning, odynophagia, and dysphagia manifest suddenly after drug ingestion, often before sleep.
    • Minimal fluid intake during medication is a common factor.

    Findings:

    • Ulceration is attributed to the drug's local cytolytic and corrosive effects due to prolonged esophageal contact.
    • Infectious causes such as cytomegalovirus and herpes simplex virus were excluded.
    • Endoscopy is crucial for confirming the clinical diagnosis.

    Implications:

    • Awareness of drug-induced esophageal ulcers is important for clinicians.
    • Patient education on proper medication intake, including sufficient fluids and avoiding bedtime dosing, is recommended.
    • Prompt diagnosis via endoscopy can prevent complications and guide treatment.

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