[Effect of 16,16-dimethyl-PG E2 on the 24 hours intragastric acidity in man]

24 hours intragastric acidity was measured in 6 healthy volunteers in 4 separate 24-hours studies, during which the subjects ate Hipp-meals and had unrestricted physical activity. The medication consisted of 1.0 microgram/kg b.w.td p.o. and 0,5 micrograms/ kg b.w. td p.o. of 16,16-dimethyl-PG E2 or placebo. 1.0 microgram/kg b.w. of 16,16-dimethyl-PG E2 decreased mean 24 hours hydrogen ion activity from 9,81 +/- 1,85 mmol/l (+/- SEM) to 4,08 +/- 1,14 mmol/l (+/- SEM). The degree of inhibition with 0,5 micrograms/kg b.w. td was significantly smaller than that due to ten higher dose of this methylated PG-analogue. Our data reveal, that lower doses of 16,16-dimethyl-PG E2 as originally believed inhibit gastric acid secretion in man effectively.