Three-dimensional shape of a Goormaghtigh cell and its contact with a granular cell in the rabbit kidney

Goormaghtigh cells of the JGA are characterized by an extensive cellular ramification. In order to elucidate the shape and arrangement of the cell processes a three-dimensional model of a Goormaghtigh cell and of an adjacent granular cell has been constructed based on electron micrographs of a series of ultrathin sections. The model shows that a Goormaghtigh cell has the shape of a flatly pressed cylinder with both ends splitting up into a bunch of parallel processes. The processes maintain a close neighboring position and do not intermingle with processes of other Goormaghtigh cells. This feature is most puzzling when considering that Goormaghtigh cells and their processes are extensively connected by gap junctions. Even processes belonging to the same cell are electrically coupled with each other through gap junctions. The granular cells are clearly different in shape from Goormaghtigh cells. In granular cells bunches of processes are lacking. Granular cells obviously ramify into a few, large processes. The present findings are consistent with the assumption of a functionally central position of Goormaghtigh cells within the feedback mechanism of the JGA.