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Prolonged, transapical left ventricular bypass (TALVB) in sheep and man
Transactions - American Society for Artificial Internal Organs
|January 1, 1978
Summary
Transapical left ventricular bypass (TALVB) shows promise for treating cardiac failure. One patient recovered myocardial function after TALVB, suggesting its potential to save lives in temporary cardiac failure cases.
Area of Science:
- Cardiovascular Surgery
- Medical Devices
- Cardiac Physiology
Background:
- Temporary cardiac failure presents a significant clinical challenge.
- Existing treatments for severe cardiac failure have limitations.
- Transapical left ventricular bypass (TALVB) is an emerging therapeutic option.
Purpose of the Study:
- To evaluate the feasibility and efficacy of TALVB in clinical settings.
- To assess the potential of TALVB to support myocardial recovery.
- To explore TALVB as a salvage therapy for temporary cardiac failure.
Main Methods:
- TALVB was performed using an LV apical cannula and roller pump system.
- Low-dose heparin anticoagulation was employed during bypass.
- Patients underwent secondary surgery for cannula removal.
Main Results:
- TALVB has been previously demonstrated in animal models (sheep, lamb).
- TALVB was applied in three clinical cases of cardiac failure.
- One patient showed recovery of myocardial function after 9 days of bypass (6 days total TALVB).
Conclusions:
- TALVB, combined with low-dose heparin and secondary cannula removal, may offer a salvage strategy.
- This approach could benefit patients experiencing temporary cardiac failure.
- Further investigation into TALVB is warranted for critical care cardiology.