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Cardiovascular complications

A V Chobanian, E R Arquilla, T B Clarkson

    Diabetes
    |January 1, 1982
    PubMed
    Summary
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    Animal models for diabetes research have varying strengths and weaknesses. Nonhuman primates show promise for cardiovascular studies, while rodents and rabbits require further investigation for their utility in understanding diabetes complications.

    Area of Science:

    • Cardiovascular Research
    • Diabetes Mellitus
    • Animal Models

    Background:

    • Diabetes mellitus significantly impacts the cardiovascular system, leading to macrovascular and cardiac complications.
    • Understanding these complications requires appropriate animal models that accurately mimic human disease pathophysiology.
    • Current animal models for diabetes research present a range of advantages and limitations for cardiovascular investigations.

    Purpose of the Study:

    • To review the current knowledge on cardiovascular aspects in various animal models of diabetes.
    • To evaluate the strengths and weaknesses of these models for studying diabetes-related cardiovascular research questions.
    • To provide recommendations for future research directions in this field.

    Main Methods:

    • Literature review and synthesis of existing research on animal models of diabetes and their cardiovascular implications.

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  • Comparative analysis of the suitability of nonhuman primates, rodents, rabbits, canines, and swine for cardiovascular research.
  • Identification of research gaps and areas requiring further investigation.

    • Main Results:

    • Nonhuman primates offer advantages for macrovascular and cardiac complication studies but face availability and cost issues.
    • Spontaneous rodent models are currently underutilized due to limited cardiovascular characterization.
    • Alloxan-diabetic rabbits show potential for atherogenesis and cardiomyopathy research, requiring further validation.
    • Canine and swine models lack sufficient data for assessing their cardiovascular research utility.
    • Several critical cardiovascular aspects, including intramyocardial circulation and autonomic function, remain understudied in diabetic animals.

    Conclusions:

    • No single animal model perfectly recapitulates all cardiovascular aspects of human diabetes.
    • Further long-term studies are needed to characterize rodent and rabbit models more thoroughly.
    • Increased research focus on neglected cardiovascular parameters and the impact of glycemic control is recommended.
    • Enhanced utilization and availability of nonhuman primate models are encouraged for advancing cardiovascular research in diabetes.