Organ removal and disappearance half-time of synthetic human pancreatic polypeptide

Human pancreatic polypeptide (HPP) was infused into 6 anesthetized dogs at a constant dose of 1.0 micrograms/kg/h over 60 min. Blood samples for RIA of pancreatic polypeptide were taken repeatedly from a carotid artery, jugular vein, femoral vein, renal vein and mesenteric vein. The calculated tissue removal of HPP in a single passage through these four vascular beds ranged from 24 to 40% and did not differ significantly among them. Mean disappearance half-time on stopping the infusion was 4.5 +/- 0,8 min. The results indicate that HPP is removed at all of the capillary beds tested.