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[Characteristics of the microbial flora of the abdominal cavity in acute appendicitis]
Abstract:
A special study of the character and sensitivity of microbic flora of the abdominal cavity exudate in acute appendicitis was carried out upon 192 patients. The predominance of infection caused by colibacillus (44%) and correlation between the severity of the inflammatory process and the presence of the agent in the exudate were proved. The identification of the sensitivity of the cultured microbes to the most widely used antibiotics allows to recommend a combined use of the preparations of neomycin sulfate group and synthetic penicillins for the treatment of complicated appendicitis.
Insights
This study on acute appendicitis found E. coli is the main cause of infection. Combining neomycin sulfate and penicillin is recommended for treating complicated appendicitis.
Area of Science:
- Microbiology
- Infectious Diseases
- Surgical Infections
Context:
- Acute appendicitis is a common surgical emergency.
- Abdominal cavity exudate analysis is crucial for understanding infection dynamics.
- Microbial flora characterization guides effective treatment strategies.
Purpose:
- To investigate the microbial flora in acute appendicitis exudate.
- To determine the antibiotic sensitivity of isolated microbes.
- To correlate microbial presence with disease severity.
Summary:
- A study of 192 patients with acute appendicitis revealed E. coli as the predominant pathogen (44%).
- A direct correlation was observed between inflammatory process severity and the presence of specific microbial agents in the exudate.
- Antibiotic sensitivity testing identified neomycin sulfate and synthetic penicillins as effective agents.
Impact:
- Provides evidence for targeted antibiotic therapy in complicated appendicitis.
- Highlights the etiological role of E. coli in acute appendicitis infections.
- Informs clinical decision-making for optimizing treatment outcomes.