[Clometacin--2. Metabolism and bioavailability in the monkey and in man]

Contrarily to the rat (see part I), clometacin is not metabolized in the monkey and in man. Urinary elimination is greater in the monkey (80 to 90% of the administered drug) than in humans (14 to 33%). Urinary excretion is rapid, i.e. more than 80% within the 24 first hours. Retention of the drug by any organ was not detected in the monkey.