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Depressed human monocyte function after influenza infection in vitro
Journal of the Reticuloendothelial Society
|December 1, 1982
Summary
Influenza virus infection significantly impairs human monocyte functions, including their ability to move, kill fungi, and engulf particles. This may explain increased susceptibility to secondary infections during flu.
Area of Science:
- Immunology
- Virology
- Cell Biology
Background:
- Influenza virus is a significant human pathogen.
- Secondary bacterial infections are a common complication of influenza, suggesting immune system impairment.
Purpose of the Study:
- To investigate the direct impact of influenza virus infection on human monocyte functions.
- To determine which specific monocyte functions are affected by influenza.
Main Methods:
- Human monocytes were isolated from healthy adults.
- Monocytes were incubated with H1N1 influenza virus or allantoic fluid.
- Five parameters of monocyte function were assessed: chemotaxis, Candida albicans killing, phagocytosis, spreading, and adhesion.
Main Results:
- Influenza virus infection markedly inhibited monocyte chemotaxis and Candida albicans killing.
- Phagocytosis was depressed, and cell spreading was slightly reduced.
- Monocyte adhesion to glass remained unaffected.
Conclusions:
- Influenza virus infection directly inhibits key human monocyte functions.
- These inhibitory effects on monocytes may contribute to the immunosuppression and increased susceptibility to secondary infections observed in influenza patients.