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Related Experiment Videos

Cranial computerized tomography in systemic lupus erythematosus

S Carette, M B Urowitz, H Grosman

    The Journal of Rheumatology
    |November 1, 1982
    PubMed
    Summary

    Cerebral atrophy on CT scans did not correlate with central nervous system systemic lupus erythematosus (CNS SLE). Findings suggest corticosteroids, not CNS SLE, may cause brain atrophy in patients.

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    Area of Science:

    • Neurology
    • Radiology
    • Immunology

    Background:

    • Central nervous system systemic lupus erythematosus (CNS SLE) is a severe complication.
    • Corticosteroids are commonly used to manage SLE but can have side effects.

    Purpose of the Study:

    • To investigate the correlation between cerebral atrophy on CT scans and CNS SLE.
    • To explore potential causes of cerebral atrophy in SLE patients.

    Main Methods:

    • Computerized tomography (CT) scans were performed on 23 patients (12 with CNS SLE, 11 controls).
    • Scans were independently reviewed by two neuroradiologists.
    • Patients were undergoing corticosteroid treatment.

    Main Results:

    • Minimal to moderate cerebral atrophy was common in both CNS SLE patients and controls.
    • No significant correlation was found between cerebral atrophy and CNS SLE.
    • Brain infarcts were observed in three patients; one showed infarct resolution on follow-up scans.
    • Steroid treatment was implicated as a potential cause of atrophy.

    Conclusions:

    • Cerebral atrophy on CT scans is not a reliable indicator of CNS SLE.
    • Corticosteroid therapy may contribute to cerebral atrophy in SLE patients.
    • Further research is needed to elucidate the role of corticosteroids in neuroinflammation and atrophy.

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