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Related Experiment Videos

Oxalosis of bone

J Wiggelinkhuizen, R M Fisher

    Pediatric Radiology
    |January 1, 1982
    PubMed
    Summary

    Primary hyperoxaluria in a child with chronic renal failure caused bone defects and increased density due to massive oxalate crystal deposition, indicating advanced bone oxalosis.

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    Area of Science:

    • Pediatric Radiology
    • Nephrology
    • Orthopedics

    Background:

    • Primary hyperoxaluria is a rare genetic disorder leading to oxalate overproduction.
    • Chronic renal failure exacerbates oxalate accumulation and systemic complications.
    • Bone involvement in primary hyperoxaluria is a significant manifestation of systemic oxalosis.

    Observation:

    • Skeletal survey in an 8-year-old girl with primary hyperoxaluria and chronic renal failure.
    • Radiographic findings included wide translucent metaphyseal bands and defects at long bone ends.
    • Disordered bone growth presented as rarefaction rims around epiphyses, patella, and tarsal bones, with generally increased bone density.

    Findings:

    • Translucent metaphyseal bands were demarcated from diaphyses by irregular dense bone lines.
    • Bone biopsy confirmed massive oxalate crystal deposition, signifying advanced bone oxalosis.
    • The radiographic and histopathological findings are consistent with severe skeletal involvement.

    Implications:

    • This case highlights the extensive skeletal manifestations of primary hyperoxaluria in pediatric patients with renal failure.
    • Early recognition of these bone changes is crucial for managing systemic oxalosis.
    • Understanding the radiographic features aids in diagnosing and monitoring bone oxalosis progression.

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