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Onset and offset of the diazepam stimulus complex

T Haug, K G Götestam

    Pharmacology, Biochemistry, and Behavior
    |December 1, 1982
    PubMed
    Summary

    Rats learned to distinguish diazepam from saline in a lever-selection task. Diazepam

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Behavioral Science

    Background:

    • Diazepam is a benzodiazepine drug with known anxiolytic and sedative effects.
    • Understanding the central versus peripheral mechanisms of drug action is crucial for pharmacology.
    • Operant conditioning procedures are valuable tools for studying drug effects on behavior.

    Purpose of the Study:

    • To investigate the discriminative stimulus properties of diazepam in rats.
    • To determine the time course and central action of the diazepam drug stimulus.
    • To assess the utility of a two-lever operant procedure for studying drug control of behavior.

    Main Methods:

    • Rats were trained to discriminate 3.0 mg/kg diazepam from saline using a two-lever operant procedure.
    • Testing involved assessing lever selection at various time points post-injection.
    • Attempts were made to establish a peripheral diazepam drug stimulus complex.

    Main Results:

    • Rats initially responded on the saline lever but shifted to the diazepam lever after training (onset).
    • A shift from the diazepam lever to the saline lever was observed at later time points (offset).
    • A peripheral diazepam drug stimulus complex could not be established, indicating central action.

    Conclusions:

    • Diazepam exerts discriminative control over lever selection in rats from 10 to 210 minutes post-injection.
    • The findings confirm a central action of the diazepam drug stimulus complex.
    • This operant conditioning method is potentially useful for studying drug control of lever selection.

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