[Anticonvulsant effects of indoline derivatives]

The anticonvulsant activities of several indoline derivatives were tested in mice using the pentetrazole (PTZ) and electroshock seizure model. Furthermore, the toxicity and the influence on hexobarbitone anaesthesia were determined. 2-oxoindoline--the most potent anticonvulsant compound--shows a characteristic modification of PTZ-induced seizures, especially a suppression of the tonic phase and a marked prolongation of survival time at lethal PTZ-doses as well as in doses of 100 mg/kg a complete protection effect to maximum electroshock. The majority of indolines possess also a marked sedative effect. The LD50 values of the derivatives under investigation are differing considerably, however, majority of compounds being within the range of 300 to 800 mg/kg (i.p.).