Fractionated irradiation and haematopoiesis. III. Effect of time interval between fractions

The effect of total single fractionated irradiation with short time interval on haematopoietic regeneration of the bone marrow and spleen was investigated. Also, the importance of first dose, when dose of 600 R was divided in two unequal fractions with time interval of 300s was studied. The investigation was performed on 25 day old rats. The dose of 600 R (X-rays) was divided on: 500 + 100, 400 + 200, 300 + 300, 200 + 400 or 100 + 500 R with time interval of 150, 300 or 600s. Ten days after irradiation the changes in blood, bone marrow and spleen were observed. After unequal fractionated dose with interval of 600s slight effect was found. The results after intervals of 600s and 300s were significant, when the total dose was divided in two equal doses. The first dose has no promoting role in haematopoietic regeneration when total dose was unequally fractionated.