[Naniprus treatment of hypertensive crises in patients with kidney diseases]

After a brief literature survey, the authors share their experience of the treatment of hypertonic crises and acute left cardiac insufficiency of renal patients via Naniprus, a preparation produced in P.R. of Bulgaria. The patients' age was from 11 to 64. With an average basal arterial pressure (AP) 25.2/14.5 kPa during the crises the patients had an average AP of 33.3/20.0 kPa and only three minutes after the initiation of its drop infusion it was reduced to an average of 25. 1/14.7 kPa (p less than 0.001). In one child with severe pulmonary edema in the progress of a hypertonic crisis, in a crisis for rejection of transplanted kidney, they infused Naniprus continuously for 5 days and nights, and in another transplanted patient--7 days and nights, not observing any undesirable effects. The authors recommend Naniprus infusion to be carried out very cautiously, with AP being checked every minute at the beginning at the other side until obtaining the desired and stable result. Each careless or uncontrolled administration of the preparation threatens with severe collapse. In patients with AV-fistulas reddening of the face and eyes as well as headache were observed.