Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Randomization for controlled therapeutic trials]

M Schemper

    Wiener Klinische Wochenschrift
    |November 26, 1982
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces adaptive randomization, an optimal method for balancing prognostic factors in clinical trials. A computer program, RANDOM, facilitates its easy and safe implementation in therapeutic trial quality control.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Statistical controversies in clinical research: the importance of importance.

    Annals of oncology : official journal of the European Society for Medical Oncology·2016
    Same author

    Parameters influencing FVIII pharmacokinetics in patients with severe and moderate haemophilia A.

    Haemophilia : the official journal of the World Federation of Hemophilia·2015
    Same author

    Lack of impact of platinum dose intensity on the outcome of ovarian cancer patients. 10-year results of a prospective randomised phase III study comparing carboplatin-cisplatin with cyclophosphamide-cisplatin.

    European journal of cancer (Oxford, England : 1990)·2003
    Same author

    New residuals for Cox regression and their application to outlier screening.

    Biometrics·2001
    Same author

    [Identification of high risk patients with severe, but asymptomatic aortic stenosis].

    Acta medica Austriaca·2001
    Same author

    A solution to the problem of monotone likelihood in Cox regression.

    Biometrics·2001
    Same journal

    [Vaccination of immunocompromised individuals: Expert opinion - update 2026].

    Wiener klinische Wochenschrift·2026
    Same journal

    Systematic review of clinical evidence for Kneipp medicine.

    Wiener klinische Wochenschrift·2026
    Same journal

    Pelvic resections in primary sarcomas : Surgical outcomes and survival analysis of 75 patients.

    Wiener klinische Wochenschrift·2026
    Same journal

    Jungmediziner*innen am Start: 11. Workshop für den medizinischen Nachwuchs.

    Wiener klinische Wochenschrift·2026
    Same journal

    Stellungnahme der ÖGP zur geplanten Gesetzesnovelle zum Nichtraucherschutzgesetz.

    Wiener klinische Wochenschrift·2026
    Same journal

    MUW researcher of the month: Dr. Moritz Schaefer.

    Wiener klinische Wochenschrift·2026
    See all related articles

    Area of Science:

    • Clinical Trials Methodology
    • Biostatistics
    • Medical Research Quality

    Context:

    • Ensuring the quality of controlled therapeutic trials is crucial.
    • The selection, organization, and implementation of randomization procedures significantly impact trial outcomes.
    • Existing randomization methods require critical evaluation for optimal application.

    Purpose:

    • To critically review available randomization procedures for clinical trials.
    • To present adaptive randomization as an optimal method for balancing prognostic factors in typical sample-sized trials.
    • To introduce the RANDOM interactive computer program for simplified and secure adaptive randomization implementation.

    Summary:

    • Adaptive randomization, as proposed by Pocock and Simon, effectively balances 2-8 prognostic factors, validated over four years of trials.

    Related Experiment Videos

  • An interactive computer program, RANDOM, is presented for user-friendly and secure application of this procedure.
  • Standardized documentation and the potential for multi-factorial trials and patient elimination are also discussed.

    • Impact:

    • Enhances the quality and reliability of controlled therapeutic trials through optimized randomization.
    • Provides a practical tool (RANDOM program) for researchers to implement advanced randomization techniques.
    • Offers support services for randomization and documentation to interested research centers.