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The mouse mutant limb-deformity (ld)

J Kleinebrecht, J Selow, W Winkler

    Anatomischer Anzeiger
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    The limb-deformity (ld) mouse mutant exhibits reduced fertility and high newborn mortality. Common defects include kidney aplasia and numerous limb malformations, such as fusions and aplasias.

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    Area of Science:

    • Developmental biology
    • Genetics
    • Teratology

    Background:

    • The limb-deformity (ld) mouse mutant is a model for studying developmental abnormalities.
    • Understanding the genetic basis of limb and kidney development is crucial.

    Purpose of the Study:

    • To characterize the phenotypic spectrum of the limb-deformity (ld) mouse mutant.
    • To document the types and frequencies of malformations observed.

    Main Methods:

    • Phenotypic analysis of homozygous limb-deformity (ld) mice.
    • Detailed examination of skeletal and organ development, focusing on limbs and kidneys.

    Main Results:

    • Homozygous ld mice display significantly reduced fertility and high neonatal mortality.

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  • Kidney aplasia (unilateral and bilateral) is a frequent phenotype, with the right side more commonly affected.
  • Extremities exhibit a wide range of malformations, including 22 types in forelimbs and 8 in hindlimbs, with primary and secondary fusions observed.

    • Conclusions:

    • The limb-deformity (ld) mutation causes severe pleiotropic effects impacting fertility, survival, kidney development, and limb morphogenesis.
    • This mutant provides a valuable model for investigating the genetic control of limb and kidney formation.