[Pharmacokinetics of cefamandole in rabbits]

The pharmacokinetics of cephamandol administered intramuscularly in single doses of 5 or 20 mg/kg and intravenously in a single dose of 5 mg/kg was studied on rabbits. When the antibiotic was administered intramuscularly, a one-compartment model was used for determination of the parameters of the antibiotic pharmacokinetics in the blood serum, while on intravenous administration of the antibiotic a two-compartment model was used. It was found that the rate of cephamandol elimination after intramuscular administration did not depend on the drug dose. The antibiotic half-life was 34-37 minutes. The apparent volume of the antibiotic distribution after intramuscular administration was 0.31-0.71 ml/g. After intravenous injection of cephamandol the apparent volume of its distribution in the central compartment was 0.27 ml/g. The stationary and kinetic volumes of the antibiotic distribution were 0.36 and 0.46 ml/g, respectively. The average values of the antibiotic elimination constant, the constant of the antibiotic passage from the central compartment to the peripheral one and vice versa were 0.0446, 0.0193 and 0.0546 min-1, respectively. After intravenous injection the rate of cephamandol elimination from the rabbit blood was higher: the antibiotic half-life after intravenous injection was 26.1 min.