Ultrastructural studies of eosinophils in passive cutaneous anaphylaxis

Kinetics and ultrastructural changes of eosinophils in passive cutaneous anaphylaxis in guinea pigs were studied. Ovalbumin was used. Skin biopsies were studied with the electron microscope. Degranulation of eosinophils in the vascular lumen, the vascular wall, and in the surrounding of vessels was noted. There was edema and degeneration of collagen fibers.