Effects of neonatal androgenization upon the pharmacological reactivity of dog uteri

The influence of androgen treatment during the neonatal period on the contractions induced in dog uteri by acetylcholine, oxytocin, histamine and barium chloride was studied in vitro. An increase in the sensitivity of preparations was observed to acetylcholine and oxytocin, represented by leftward shifts in the ED50 values of these agonists. On the other hand the ED50 values for histamine and barium chloride remained unchanged. The relative responsiveness (p) remained unaltered for all the agonists studied. These effects differ from those observed in the uterus of neonatally androgenized female rats.