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Metabolism and acid-base physiology

Artificial Organs

|November 1, 1982

Summary

This summary is machine-generated.

Intermediary metabolism significantly impacts acid-base balance. Protein oxidation, particularly of certain amino acids, generates the primary acid load, while anionic amino acids aid in proton removal.

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Area of Science:

Biochemistry
Physiology

Background:

Acid-base balance is crucial for physiological function.
Intermediary metabolism generates and removes hydrogen ions, influencing acid-base status.

Purpose of the Study:

To review hydrogen ion production and removal pathways in intermediary metabolism.
To provide a theoretical framework for understanding acid-base balance shifts.

Main Methods:

Theoretical analysis of metabolic pathways.
Evaluation of contributions from carbohydrate, lipid, protein, phospholipid, and purine oxidation.
Consideration of calcium-mediated reactions.

Main Results:

Protein oxidation, especially of cationic and sulfur-containing amino acids, is a major source of acid load.

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Anionic amino acid oxidation and metabolizable organic anions contribute to proton removal.

Calcium reactions, such as precipitation, can liberate protons.

Conclusions:

Clinicians can estimate acid production rates by considering these metabolic pathways.
Carbohydrates and neutral lipids have minimal impact on acid-base balance under normal conditions without hypoxia or insulin deficiency.