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Abstract:
A pepsinogen (Pg 1) polymorphism was observed in gastric mucosal samples of Wistar rats by polyacrylamide slab gel electrophoresis. Three phenotypes were observed: S (a slow-moving band), F (a fast-moving band), and FS (both bands). Pg 1 variation was controlled by a pair of codominant alleles at a single autosomal locus. Interstrain variation of Pg 1 was studied in five strains of laboratory rats. Genetic variation of Pg 1 was detected only in the Wistar strain.