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Related Experiment Videos

Investigation of cerebral function in elderly patients

C M Castleden

    Gerontology
    |January 1, 1982
    PubMed
    Summary

    Measuring drug effects on elderly CNS function requires multiple safe, non-invasive methods like Electroencephalogram (EEG) and psychomotor tests. Careful subject selection and study design are crucial for reliable drug therapy research.

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    Area of Science:

    • Neuroscience
    • Gerontology
    • Pharmacology

    Background:

    • Assessing drug impacts on central nervous system (CNS) function in elderly individuals is feasible using various methods.
    • Current techniques are safe, non-invasive, and well-tolerated by participants, but each has limitations.

    Purpose of the Study:

    • To review and highlight effective methods for measuring drug effects on CNS function in the elderly population.
    • To emphasize the importance of appropriate methodology and study design in geriatric psychopharmacology research.

    Main Methods:

    • Discusses Computerised Axial Tomography (CAT) scanning for subject selection.
    • Highlights Cerebral Blood Flow (CBF) studies using xenon-133 for subject selection and drug effect assessment.
    • Emphasizes Electroencephalogram (EEG) for objective measurement of drug onset, duration, and minimum effective dose.
    • Includes psychomotor tests assessing performance, memory, learning, and physical parameters like sway.
    • Recommends visual analogue scales for subjective assessments.

    Main Results:

    • EEG and psychomotor tests are identified as principle investigative techniques for drug efficacy.
    • CBF studies with xenon-133 show potential for research but are currently underutilized.
    • CAT scanning is useful for subject selection but not sensitive enough for research.

    Conclusions:

    • No single method is sufficient; a combination of techniques is recommended for comprehensive assessment.
    • Rigorous study design, including careful subject selection, double-blinding, and inclusion of placebos or reference drugs, is paramount.
    • Future research should further explore the utility of CBF studies in evaluating drug effects on cerebral activity in the elderly.

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