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[Cardiovascular changes during ethanol-tocolysis]

W Lauckner, U Retzke, R Schwarz

Zentralblatt Fur Gynakologie

|January 1, 1978

Summary

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Ethanol and fructose infusions in late pregnancy caused favorable hemodynamic changes, including increased cardiac output. However, ethanol should be used cautiously for short-term tocolysis due to potential risks.

Area of Science:

Obstetrics and Gynecology
Cardiovascular Physiology
Pharmacology

Context:

Investigating the cardiovascular impact of intravenous ethanol-fructose solutions in late pregnancy.
Utilizing quantitative sphygmometry to assess hemodynamic parameters.
Focusing on healthy women in the late stages of gestation.

Purpose:

To evaluate the cardiovascular effects of a 5% ethanol-10% fructose solution infusion.
To determine changes in arterial pressure, cardiac output, and peripheral resistance.
To assess the safety and efficacy of ethanol for short-term tocolysis.

Summary:

Intravenous infusion of a 5% ethanol-10% fructose solution in 10 healthy late-pregnant women showed insignificant changes in arterial pressure.
Significant increases in stroke volume, cardiac output, and cardiac work/power were observed.

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A notable decrease in total peripheral resistance and a constant heart rate were recorded.

Impact:

The study highlights favorable hemodynamic alterations during ethanol-fructose infusion in late pregnancy.
Findings suggest ethanol may have a role in short-term tocolysis, but caution is advised.
Results contribute to understanding the cardiovascular physiology of pregnant women under specific infusions.