[Humoral and cellular immunity in uremia]

Uremia is a metabolic imbalance accompanied by an acquired immunologic deficiency state. Fatal infections frequently met with uremia may be explained both by cellular and humoral immunologic disorders. In this article, the cellular immune status was investigated via intradermal skin test, and the serum and cerebrospinal fluid (CSF) immunoglobulins were detected. Results indicated that a cellular and humoral immunologic deficiency, which deteriorated in accordance with the clinical status, existed and a CSF immunoglobulin increase, presumably due to changes in the blood - CSF barrier, was noted.