The effect of prostaglandins on climbing behavior induced by apomorphine in mice

Prostaglandins E2, F2 alpha, D2 and I2 administered intracerebroventricularly in a dose of 1 microgram, inhibited the climbing behavior induced by apomorphine. The most active in this respect was PGE2, the least--PGD2. The results indicate the participation of prostaglandins in the regulation of central dopaminergic function.