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Creatine kinase and creatine kinase subunit-B in coronary sinus blood in pacing-induced angina pectoris
Scandinavian Journal of Clinical and Laboratory Investigation
|December 1, 1982
Insights
Pacing-induced angina in coronary artery disease patients caused the heart to produce lactate. However, no significant release of creatine kinase or its subunit-B was detected in blood samples.
Area of Science:
- Cardiology
- Biochemistry
Background:
- Coronary artery disease (CAD) is a major cause of morbidity and mortality.
- Understanding the biochemical markers of myocardial ischemia is crucial for diagnosis and management.
Purpose of the Study:
- To investigate the biochemical changes in myocardial metabolism during pacing-induced angina in patients with CAD.
- To determine if lactate, creatine kinase (CK), or creatine kinase subunit-B (CK-BB) are released into circulation during ischemic episodes.
Main Methods:
- Patients with angiographically documented CAD underwent pacing-induced angina.
- Blood samples were collected from the coronary sinus and peripheral veins.
- Lactate, CK, and CK-BB levels were measured.
Main Results:
- Nine out of 10 patients showed increased myocardial lactate production during pacing-induced angina.
- No significant release of CK or CK-BB was detected in either coronary sinus or peripheral venous blood.
Conclusions:
- Pacing-induced angina provokes myocardial lactate production in most CAD patients.
- CK and CK-BB are not reliable markers of acute myocardial metabolic changes during pacing-induced angina in this setting.
Abstract:
In nine out of 10 patients with angiographic documented coronary artery disease, pacing-induced angina pectoris provoked myocardial production of lactate, whereas no significant release of either creatine kinase or creatine kinase subunit-B to coronary sinus and peripheral venous blood could be detected.