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Age-related reference intervals for creatine kinase BB in serum
Scandinavian Journal of Clinical and Laboratory Investigation
|December 1, 1982
Summary
Serum creatine kinase BB (CK-BB) levels decrease significantly with age, particularly in the first year of life. Boys aged 14 showed a transient increase in CK-BB compared to girls.
Area of Science:
- Biochemistry
- Pediatrics
- Clinical Chemistry
Background:
- Creatine kinase BB (CK-BB) is an isoenzyme found in serum.
- Understanding CK-BB concentration changes across different age groups is crucial for establishing reference intervals.
Purpose of the Study:
- To measure CK-BB mass concentration in healthy individuals across various age groups.
- To establish age-specific reference intervals for CK-BB.
- To investigate the relationship between CK-BB mass and activity.
Main Methods:
- Radioimmunoassay was used to measure CK-BB mass concentration in serum.
- Serum samples were collected from 365 healthy individuals across eight age groups.
- Immuno-inhibition techniques were employed to estimate CK-BB activity.
Main Results:
- CK-BB concentration generally decreased with age, with most significant changes occurring within the first year of life.
- Median CK-BB levels at 1 year were 1/15th of birth levels and 1/2 of 4-day-old levels, but four times higher than adult levels.
- A transient increase in CK-BB was observed in 14-year-old boys, with significantly higher levels than girls at this age.
- CK-BB mass and activity showed a high correlation (r=0.98) in cord blood samples.
Conclusions:
- Age-dependent reference intervals for CK-BB are essential, with a notable decline in the first year.
- A transient peak in CK-BB in adolescent boys warrants further investigation.
- CK-BB mass concentration is a reliable indicator of enzyme activity.