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Age-related reference intervals for creatine kinase BB in serum

P Urdal, K Urdal, J H Strømme

    Scandinavian Journal of Clinical and Laboratory Investigation
    |December 1, 1982
    PubMed

    Insights

    Serum creatine kinase BB (CK-BB) levels decrease significantly with age, particularly in the first year of life. Boys aged 14 showed a transient increase in CK-BB compared to girls.

    Area of Science:

    • Biochemistry
    • Pediatrics
    • Clinical Chemistry

    Background:

    • Creatine kinase BB (CK-BB) is an isoenzyme found in serum.
    • Understanding CK-BB concentration changes across different age groups is crucial for establishing reference intervals.

    Purpose of the Study:

    • To measure CK-BB mass concentration in healthy individuals across various age groups.
    • To establish age-specific reference intervals for CK-BB.
    • To investigate the relationship between CK-BB mass and activity.

    Main Methods:

    • Radioimmunoassay was used to measure CK-BB mass concentration in serum.
    • Serum samples were collected from 365 healthy individuals across eight age groups.
    • Immuno-inhibition techniques were employed to estimate CK-BB activity.

    Main Results:

    • CK-BB concentration generally decreased with age, with most significant changes occurring within the first year of life.
    • Median CK-BB levels at 1 year were 1/15th of birth levels and 1/2 of 4-day-old levels, but four times higher than adult levels.
    • A transient increase in CK-BB was observed in 14-year-old boys, with significantly higher levels than girls at this age.
    • CK-BB mass and activity showed a high correlation (r=0.98) in cord blood samples.

    Conclusions:

    • Age-dependent reference intervals for CK-BB are essential, with a notable decline in the first year.
    • A transient peak in CK-BB in adolescent boys warrants further investigation.
    • CK-BB mass concentration is a reliable indicator of enzyme activity.

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