[Intracranial metastases in neuroblastomas]

Primary extracranial neuroblastomas frequently metastasize into calvaria, orbita and dura. A direct infiltration is known as secondary metastases to the brain, if the lesion penetrates the bone and dura. Primary metastases to the brain without lesions of the calvaria or dura were observed rarely in extracranial neuroblastomas very interesting with respect to the pathway of metastases. Only a in one of our cases a secondary metastases to the brain could be seen among 21 autopsies. A primary metastases to the brain was diagnosed in a child with a presacral neuroblastoma in the true pelvin. No extracranial metastases could be found, further cases are reviewed from the literature.