[Evaluation of cefsulodin in the field of pediatrics]

A few studies on cefsulodin (CFS) were performed and the following results were obtained. 1. High blood concentration was obtained with intravenous drip infusion of this drug, but it did not last long. 2. In 6 to 12 hours after the conclusion of the infusion, 52-81% of the dose was excreted in active condition. 3. Pseudomonas aeruginosal abscess was completely cured by intravenous drip infusion of this drug. A decrease in Pseudomonas aeruginosa was noted in urine in the case of acute pyelonephritis and in sputum in the case of pneumonia. The minimum inhibitory concentrations of this drug against P. aeruginosa isolated from various materials were below 12.5 micrograms/ml for all strains. 4. In all the patients including 3-month-old infants to whom 55-200 mg/kg of this drug was intravenously drip infused for 5 days, systemic or topical adverse reactions were not recognized. Nor did this drug give any effect on general blood condition, and liver and kidney functions. We plan to further study the clinical efficacy of this drug by adding more cases affected with P. aeruginosa in children.