[Morphology and biochemistry of wound healing]

Wound healing was investigated by morphological and biochemical methods. The results show that wounds cause disturbances in the equilibrium between the physiological anabolic and catabolic processes of cells, ground substance, and fibers (with increased turnover rates). The primary increase of catabolism is responsible for the secondary compensatory enhanced anabolism, especially of proteoglycans and collagen. Kind, size, and localization of wounds determine the course of wound healing and therefore the extent of adaptation of structure, function, and biomechanical capacities on the surrounding uninjured tissue.