Related Experiment Video

Updated: Aug 18, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

[Inflammatory bowel disease in childhood]

J W Booth, J T Harries

    La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
    |July 1, 1982
    PubMed

    Insights

    Childhood inflammatory bowel disease (IBD) incidence is rising. Early diagnosis and multidisciplinary care, including nutrition and psychosocial support, improve outcomes for pediatric Crohn's disease and ulcerative colitis patients.

    Area of Science:

    • Pediatric Gastroenterology
    • Inflammatory Bowel Disease (IBD) Research

    Context:

    • Increasing incidence of pediatric inflammatory bowel disease (IBD) over the last two decades.
    • Insidious onset of Crohn's disease symptoms, like growth failure, can delay diagnosis.

    Purpose:

    • To review the diagnosis and management of pediatric IBD, focusing on Crohn's disease and ulcerative colitis.
    • To discuss the role of pediatric colonoscopy, drug therapy, nutritional support, and surgical indications.

    Summary:

    • Paediatric colonoscopy aids in diagnosing IBD, with characteristic macroscopic and microscopic findings.
    • Effective management includes drug therapy, nutritional support for growth failure, and timely surgical intervention when necessary.
    • A multidisciplinary approach is crucial, especially for severe colitis requiring early surgery.

    Impact:

    • Optimized management strategies can lead to favorable outcomes for most children with IBD.
    • Successful adaptation to stoma therapy is achievable with adequate psychosocial preparation and support post-proctocolectomy.

    More Related Videos

    Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice07:34

    Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

    Published on: December 16, 2021

    Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis09:44

    Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

    Published on: October 14, 2025

    Related Concept Videos

    Chronic Bowel Disorders: Introduction01:17

    Chronic Bowel Disorders: Introduction

    Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
    Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
    Inflammatory Bowel Disease I: Ulcerative Colitis01:27

    Inflammatory Bowel Disease I: Ulcerative Colitis

    Introduction
    Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
    Risk Factors
    The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
    Inflammatory Bowel Disease II: Crohn's Disease01:30

    Inflammatory Bowel Disease II: Crohn's Disease

    Introduction
    Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
    Crohn's disease
    Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
    Inflammatory Bowel Disease I: Introduction01:26

    Inflammatory Bowel Disease I: Introduction

    Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
    Inflammatory Bowel Disease II: Ulcerative Colitis01:20

    Inflammatory Bowel Disease II: Ulcerative Colitis

    Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
    Inflammatory Bowel Disease III: Crohn's Disease01:25

    Inflammatory Bowel Disease III: Crohn's Disease

    Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...