Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cholesterol kinetics in control and hypercholesterolemic foxhounds

W C Kent, J E Whitney

    Artery
    |January 1, 1982
    PubMed
    Summary

    This study reveals that cholesterol excretion rate and volume are key factors in maintaining cholesterol homeostasis. Hypercholesterolemic foxhounds showed impaired cholesterol regulation, highlighting excretion

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The effect of ethanol and/or acetaldehyde on the incorporation of U14C-glucose into human umbilical artery lipids.

    Artery·1983
    Same author

    The effect of contraceptive steroids on the incorporation of U14C-glucose into porcine aortic lipids.

    Artery·1981
    Same author

    Effects of tolbutamide and glyburide on glucose and acetate incorporation into aortic lipids of the dog.

    Blood vessels·1980
    Same author

    The effects of elevated glucose levels on the incorporation of glucose and acetate into aortic lipids of the dog.

    Paroi arterielle·1978
    Same author

    Cytologic evaluation of experimental type 2 herpes simplex infection in mice.

    Acta cytologica·1978
    Same author

    Acquisition of Type 1 herpes simplex vulvitis within a monogamous relationship.

    The British journal of venereal diseases·1978

    Area of Science:

    • Metabolic Physiology
    • Cardiovascular Research
    • Animal Models

    Background:

    • Hypercholesterolemia is a significant risk factor for atherosclerosis.
    • Understanding cholesterol metabolism is crucial for developing effective treatments.

    Purpose of the Study:

    • To investigate cholesterol metabolism kinetics in hypercholesterolemic foxhounds.
    • To identify kinetic parameters correlated with atherosclerosis development.

    Main Methods:

    • Induction of hypercholesterolemia via thyroidectomy and cholesterol feeding in foxhounds.
    • Administration of tracer cholesterol (oral and IV) and sequential serum sampling.
    • Analysis of serum and tissue cholesterol radioactivity and kinetic modeling.

    Main Results:

    • Hypercholesterolemic dogs exhibited elevated liver cholesterol concentrations.
    • Atherosclerosis severity correlated with the size of cholesterol pool 2.
    • Cholesterol absorption was similar between hypercholesterolemic and control dogs.
    • A third, slow cholesterol pool (T 1/2 > 200 days) was identified.
    • Bile cholesterol kinetics indicated derivation from the slow pool.

    Conclusions:

    • Cholesterol excretion rate and volume are critical for maintaining cholesterol homeostasis.
    • Impaired excretion contributes to the inability to regulate cholesterol levels during high intake.
    • A slow-turnover cholesterol pool plays a significant role in overall cholesterol balance.

    Related Experiment Videos