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Decrease of serum oestriol during intravenous hexoprenaline or salbutamol treatment

M Haukkamaa, M Gummerus

    British Journal of Obstetrics and Gynaecology
    |November 1, 1982
    PubMed
    Summary
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    Maternal serum estriol monitoring is unreliable during intravenous beta-mimetic therapy for preterm labor. Estriol levels decrease during treatment but return to normal after stopping the infusion, masking fetal well-being.

    Area of Science:

    • Obstetrics and Gynecology
    • Maternal-Fetal Medicine
    • Pharmacology

    Background:

    • Premature labor management often involves beta-mimetic agents.
    • Accurate fetal monitoring is crucial in managing preterm labor.
    • Maternal serum estriol levels have been used as a fetal well-being indicator.

    Purpose of the Study:

    • To evaluate the reliability of maternal serum total estriol measurements for fetal monitoring during intravenous beta-mimetic therapy.
    • To assess the impact of hexoprenaline and salbutamol infusions on serum estriol levels.

    Main Methods:

    • A study involving patients with premature labor treated with intravenous hexoprenaline or salbutamol.
    • Serum total estriol levels were measured using radioimmunoassay every 6 hours during intravenous infusion.

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  • Measurements were continued for 4 days after stopping the intravenous treatment.

    • Main Results:

    • A significant decrease in mean serum total estriol concentration was observed during intravenous beta-mimetic treatment.
    • Serum estriol levels returned to pre-treatment levels after the cessation of intravenous therapy.

    Conclusions:

    • Maternal estriol determination is not a reliable method for fetal monitoring when patients are receiving intravenous beta-adrenoceptor agonist therapy.
    • The observed changes in estriol levels are likely influenced by the medication, not solely by fetal status.