[Effect of histamine and thymarin on blood coagulation and fibrinolysis in intact and thymectomized rats]

It was discovered in experiments on thymectomized rats that the animals developed hypercoagulation due to the shortening of prothrombinase formation time and to the inhibition of total and Hageman-dependent euglobulin fibrinolysis 2-3 months after the operation. As compared to the intact animals, administration of histamine to the thymectomized animals led to unbalance between marked acceleration of blood coagulation and a comparatively insignificant activation of fibrinolysis. This was one of the main causes of the death of the operated on animals. Low-molecular thymus factor--thymaline--not only abolishes the shifts on the part of the hemostatic system in the thymectomized animals but also recovers adequate responses of the blood coagulation and fibrinolysis systems to histamine administration, thereby contributing to the life preservation of the experimental animals.