Fatty acid composition of synaptosomes from normal and cobalamin deficient bat brain

1. Synaptosomes were prepared from the brain of cobalamin deficient and cobalamin supplemented fruit bats (Rousettus aegyptiacus) by a floatation method on a discontinuous sucrose gradient. 2. There were no significant differences in fatty acid composition between the deficient and supplemented bats. 3. The odd chain fatty acid 15:0 amounted to 0.2% of the total fatty acids in both groups. 4. We conclude that the fatty acids of synaptosomal lipids are not a factor in the development of neural dysfunction in the cobalamin deficient fruit bat.