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Related Experiment Videos

Implanted electroenzymatic glucose sensors

L C Clark, C A Duggan

    Diabetes Care
    |May 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    This study explores using a glucose sensor for in vivo monitoring. The electrochemical sensor demonstrated rapid, specific glucose measurement in animal models and maintained performance over ten months.

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    Area of Science:

    • Biomedical Engineering
    • Analytical Chemistry
    • Clinical Diagnostics

    Background:

    • Electrochemical sensors have advanced critical care diagnostics, enabling intermittent and continuous monitoring of blood gases and ions.
    • The development of electroenzymatic sensors has spurred research into metabolic monitoring, particularly for glucose.
    • Existing glucose sensors, designed for ex vivo analysis, are being investigated for in vivo applications.

    Purpose of the Study:

    • To evaluate the feasibility of using a specific glucose sensor for in vivo intravascular or tissue-implanted applications.
    • To assess the sensor's performance and stability for continuous glucose monitoring within biological environments.

    Main Methods:

    • The study utilized a polarographic glucose sensor based on glucose oxidase (EC 1.1.3.4).

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  • The sensor featured a dual-membrane system to selectively measure hydrogen peroxide generated from glucose, while excluding interfering substances like ascorbic acid.
  • In vivo testing involved acute subcutaneous implantation in cats and dogs, and integration into venous catheters.

    • Main Results:

    • The electrochemical glucose sensor exhibited rapid and specific responses upon acute subcutaneous implantation in animal models.
    • The sensor functioned effectively when incorporated into glucose-sensor-tipped venous catheters.
    • One sensor maintained consistent response characteristics for in vitro, subcutaneous, and blood glucose monitoring over a ten-month period, including cold storage between uses.

    Conclusions:

    • The explored glucose sensor shows promise for in vivo intravascular or tissue-implanted applications in metabolic monitoring.
    • The sensor's stability and specific response characteristics suggest its potential for long-term in vivo glucose monitoring.
    • Further development could lead to advanced continuous glucose monitoring systems for clinical use.