Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does cantharides blister fluid provide access to the peripheral compartment?

M Schäfer-Korting, H C Korting, S Hiemstra

    European Journal of Clinical Pharmacology
    |October 1, 1982
    PubMed
    Summary

    Bendroflumethiazide (BFT) pharmacokinetics were studied in healthy volunteers. Cantharides blister fluid can reflect BFT levels in the body's peripheral compartment, aiding pharmacokinetic research.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Ultrastructural calcium distribution and myocardial calcium content in human idiopathic dilated cardiomyopathy.

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
    Same author

    Variations of in vitro nitroglycerine permeation through human epidermis.

    Pharmaceutical research·2013
    Same author

    Pharmacodynamics of basic triamterene derivatives.

    Pharmaceutical research·2013
    Same author

    Evidence for an acute antimagnesiuretic effect of triamterene derivatives.

    Pharmaceutical research·2013
    Same author

    Torasemide significantly reduces thiazide-induced potassium and magnesium loss despite supra-additive natriuresis.

    European journal of clinical pharmacology·2009
    Same author

    Pharmacology of intracellular cytosine-arabinoside-5'-triphosphate in malignant cells of pediatric patients with initial or relapsed leukemia and in normal lymphocytes.

    Cancer chemotherapy and pharmacology·2006

    Area of Science:

    • Pharmacology
    • Clinical Pharmacy
    • Drug Metabolism

    Background:

    • Understanding drug distribution is crucial for optimizing therapeutic efficacy.
    • Bendroflumethiazide (BFT) is a commonly prescribed diuretic.
    • Investigating alternative biological matrices for drug monitoring is essential.

    Purpose of the Study:

    • To evaluate the pharmacokinetic profile of bendroflumethiazide (BFT) after oral administration.
    • To determine if cantharides blister fluid can serve as a surrogate for peripheral compartment drug concentrations.
    • To assess the utility of blister fluid in pharmacokinetic investigations.

    Main Methods:

    • Oral administration of 10 mg bendroflumethiazide (BFT) to 3 healthy volunteers, with each subject participating twice.

    Related Experiment Videos

  • Measurement of BFT concentrations in plasma and cantharides blister fluid over 30 hours post-dose.
  • Analysis of plasma BFT levels using tri-exponential equation fitting to calculate peripheral compartment concentrations.

    • Main Results:

    • Cantharides blister fluid BFT levels generally paralleled peripheral compartment concentrations in 5 out of 6 investigations.
    • Mean blister fluid BFT concentrations were 1.46-fold higher than calculated concentrations in Compartment 2.
    • One subject showed blister fluid paralleling plasma levels, potentially due to delayed blister formation.

    Conclusions:

    • Cantharides blister fluid appears to represent the peripheral compartment for bendroflumethiazide (BFT) distribution.
    • Blister fluid analysis offers a potential non-invasive method for pharmacokinetic studies.
    • Further research is warranted to explore the broader application of blister fluid in drug monitoring.