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Related Experiment Videos

Virological changes in chronic hepatitis type B treated with levamisole

G Fattovich, P Cadrobbi, C Crivellaro

    Digestion
    |January 1, 1982
    PubMed
    Summary

    Long-term levamisole therapy showed promise for children with chronic hepatitis B. Most patients experienced normalized liver enzymes and improved liver histology after treatment for hepatitis B e antigen-positive chronic hepatitis.

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    Area of Science:

    • Hepatology
    • Immunology
    • Pediatrics

    Background:

    • Chronic hepatitis B infection affects numerous children worldwide.
    • Hepatitis B e antigen (HBeAg) positivity indicates active viral replication and infectivity.
    • Chronic active hepatitis requires effective therapeutic interventions.

    Purpose of the Study:

    • To evaluate the efficacy of levamisole in treating HBeAg-positive chronic hepatitis B in children.
    • To assess the impact of levamisole on viral markers and liver histology.

    Main Methods:

    • Eight children with HBeAg-positive chronic active hepatitis B received levamisole (2.5 mg/kg/day, twice weekly for 6-18 months).
    • Treatment outcomes were monitored through liver enzyme levels, serological markers (HBeAg, anti-HBe), HBV-DNA polymerase, and liver biopsy.

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  • Response patterns were analyzed based on pretreatment transaminase levels and liver hepatitis B core antigen (HBcAg) expression.

    • Main Results:

    • Six of eight children achieved normalized transaminases within 4-18 months.
    • These responders demonstrated seroconversion to anti-HBe and clearance of HBV-DNA polymerase and HBcAg.
    • Post-treatment biopsies showed regression from chronic active hepatitis to chronic persistent hepatitis.
    • Two response patterns were observed: early normalization in patients with higher initial transaminases and lower HBcAg, and delayed response in those with less active disease and higher HBcAg expression.

    Conclusions:

    • Long-term levamisole therapy appears beneficial for HBeAg-positive chronic hepatitis B in children.
    • Levamisole treatment can lead to biochemical and histological improvements.
    • Treatment duration and response may correlate with disease activity and viral antigen expression.